
Frontiers in Marine Science | New and Recent Articles
Molecular characterization of hypoxia-inducible factor alpha isoforms reveals a pivotal role of HIF-3α in acute hypoxia adaptation of greenfin horse-faced filefish (Thamnaconus septentrionalis)
Hypoxia-inducible factor alpha (HIF-α) family members play crucial roles in cellular responses to low oxygen levels, yet their specific functions in the greenfin horse-faced filefish (Thamnaconus septentrionalis) remain poorly understood. This study investigates the hypoxia sensitivity of T. septentrionalis, identifying a critical oxygen tension for loss of equilibrium (LOEcrit) at 1.43 ± 0.2 mg/L. Through phylogenetic and structural analyses, three TsHIF-α isoforms were characterized, revealing that TsHIF-










